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Entered 2024.12.22 12:00 Modified 2024.12.22 12:00 Reporter Kim So-hee (hee@dailian.co.kr)
Professor Kwang-Hyeon Cho’s research team in the Department of Bio and Brain Engineering discovers a reversible treatment technology for colorectal cancer.
Department of Bio and Brain Engineering, doctoral candidate Joo-hee Kim, doctoral student Gongryeol Jeong, Professor Gwang-hyeon Cho, doctoral candidate Chun-kyung Lee, and doctoral candidate Hoon-min Kim. ⓒKorea Advanced Institute of Science and Technology
The Korea Advanced Institute of Science and Technology (KAIST) announced on the 22nd that it has developed an original technology to treat cancer cells by returning them to normal cells.
Professor Kwang-Hyeon Cho’s research team in the Department of Bio and Brain Engineering developed an original technology for reversible treatment of colon cancer that can be treated without side effects by changing the state of colon cancer cells without killing them and returning them to a state similar to normal colon cells.
The research team focused on the observation that the normal cell differentiation trajectory is reversed during the process of normal cells becoming cancerous. Based on this, we developed a technology to create a digital twin of the genetic network for the differentiation trajectory of normal cells.
Through simulation analysis, we systematically explored the master molecular switch that induces normal cell differentiation. It was proven through molecular cell and animal experiments that when discovered and applied to colon cancer cells, the condition of the colon cancer cells was normalized.
This research outcome is the development of original technology that shows that reversing cancer cells into normal cells can be achieved through a systematic approach by producing and analyzing digital twins of cancer cell genetic networks rather than relying on accidental discovery.
The research team explained that it is significant in suggesting that it is possible to develop a reversible treatment for cancer by applying the technology to various other types of cancer.
Professor Kwang-Hyeon Cho said, “It is an amazing phenomenon that cancer cells can be converted into normal cells. This achievement proves that this can be systematically induced.”
He continued, “The results of this research are based on the results of first presenting the concept of reversible treatment that returns cancer cells to normal cells, and the development of original technology to discover treatment targets for cancer reversibility by systematically analyzing the differentiation trajectory of normal cells.” did it
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2024-12-22 04:13:00